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"Obesity immunity" drug a step closer thanks to silencing Mitch

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Following on from a remarkable study in mice, scientists have now confirmed that silencing a certain protein in muscle tissue leads to energy-deprived human cells seeking out fat for fuel, while blocking the body's ability to store extra fat cells.

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Category: Obesity, Illnesses and conditions, Body & Mind

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'Flavodiet' – a simple way to reduce signs of unhealthy aging

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Consuming a diet high in berries, black tea, citrus fruits and apples – foods that are rich in flavonoids – can reduce the signs of unhealthy aging, according to a new study. It highlights how simple dietary changes can optimize health and improve quality of life.

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Category: Wellness & Healthy Living, Body & Mind

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Wildly overpowered ebike lets you pedal along at highway speeds

Gizmag news -

We were stunned at the power and sheer audacity of the Stealth B-52 back in 2015 when we first rode it. Ebikes still felt like a pretty new thing at the time, and this Aussie monster threw all questions of street legality out the window to show what these machines could be without regulatory shackles holding them back.

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Category: Bicycles, Transport

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New storm-ready ultralight dome tent doubles capacity, not weight

Gizmag news -

A new generation of freestanding ultralight tents has been rolling out over the past year or so to make backpacking and other backcountry activities more convenient than ever. Durston Gear's X-Dome 1+ hit what might just be the best ounce-to-dollar value point of the bunch, and now the all-new X-Dome 2 builds on that by adding more spacious two-person sizing at a minimal weight penalty. The X-Dome 2 also packs in the value Durston has come to represent, along with storm-shedding ruggedness ready for everything from short downpours to surprise high-alpine snow squalls.

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Category: Outdoors, Lifestyle

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Sigma America announces a price increase on lenses due to US tariffs

Digital Photography Review news -

Image: Sigma

Sigma, a Japanese company that designs and manufactures lenses and accessories for a wide range of camera systems, including Sony, Fujifilm, Canon, Nikon and its own cameras is the latest to announce US pricing adjustments due to government-imposed tariffs. The news was delivered via an apologetic letter from Sigma America's president, Mark Amir-Hamzeh. Price increases on its products will take effect on Monday, June 2nd.

"Due to the recent implementation of government-imposed tariffs, our costs at Sigma America have increased substantially. We have made every effort to absorb these added expenses, but the sustained impact of the tariffs now necessitates a price increase to ensure we can continue delivering the quality and service you expect," Amir-Hamzeh stresses.

Orders placed between now and May 31st won't be impacted, and current pricing will still apply. Sigma hasn't specified how much prices will increase, simply saying there will be a "pricing adjustment." The new tariff-adjusted pricing will take effect on June 2nd and will apply to any new or unfulfilled US orders from then onward. Sigma joins Tamron, Canon and a growing list of camera manufacturers whose bottom line is being impacted on the growing cost of conducting business in the US.

Brain retraining therapy offers new hope for chronic pain sufferers

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What if the key to reducing your chronic pain was not in tackling the symptoms, but in regulating your emotions? A recent study shows that retraining your brain to deescalate negative emotions and enhance positive ones could be an effective therapy for persistent and long-lasting pain.

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Category: Chronic Pain, Illnesses and conditions, Body & Mind

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DJI drops teaser clip ahead of next week's product launch

Digital Photography Review news -

Early this morning, DJI released a teaser announcement on its social media channels. The video clip titled "Spin Your World" clocks in at less than 10 seconds. It opens with an aerial landscape shot of snowy mountains and a slight rolling gimbal movement. Coupled with the closing shot of two arms at the forefront and a tri-camera system with the word "Hasselblad" inscribed on top, it appears that DJI is releasing a follow-up to its Mavic 3 series drone.

Leaks of DJI's products and their rumored specs flood online sites and forums months before release. If an overwhelming amount of speculation turns out to be correct, the Mavic 4 Pro will launch next week. As you can tell from the video, DJI has moved away from its traditional boxy camera system for a more spherical design. While it looks odd, the gimbal is rumored to allow more flexibility by enabling the camera to roll up to 175º while tilting in a range of -90º to +70º.

DJI will release all the details surrounding its highly anticipated latest release on Tuesday, May 13th, starting at 12:00 PM, GMT (8:00 AM, EST/5:00 AM, PST).

Canon EOS R50 vs EOS R50 V: what do you want to create?

Digital Photography Review news -

When you use DPReview links to buy products, the site may earn a commission.Canon EOS R50 vs R50 V

Canon recently announced the EOS R50 V, a camera aimed at creators looking to shoot high-quality video without spending a ton of money. However, it made similar claims about the original EOS R50, which – unsurprisingly, given the name – the EOS R50 V shares a lot of DNA with. They have the same 24MP APS-C sensor and many of the same features.

So what are the differences between the two, and which one should you buy? We'll aim to break it down in this comparison.

Buy now:

Buy w/ 14-30mm at Amazon.comBuy w/ 14-30mm at B&H PhotoBuy w/ 14-30mm at Canon Design

Even at a glance, it's easy to tell that these cameras are aimed at different audiences. The EOS R50 looks like a small stills camera, with a relatively deep front grip and a prominent hump at the top for the electronic viewfinder and pop-up flash. On the top is a relatively standard stereo microphone.

The EOS R50 V does away with the viewfinder and flash, giving it a much boxier and slightly larger design. Its grip is less prominent, though this has the effect of making it more comfortable to hold when it's facing toward you. There's also a record button on the front, along with a tally light to make it obvious when you're recording, both of which can be quite useful when you're trying to film yourself. It has an upgraded internal microphone, which Canon says has three capsules to help make audio clearer and to reduce noise. We've found it provides decent audio for vlogging, as long as there's no wind.

The EOS R50 V has an extra tripod mount for vertical shooting.

Both cameras have tripod sockets on the bottom, but the EOS R50 V has an additional one on its right side, making it easy to mount it vertically.

Handling / Controls

The EOS R50 has a shutter button towards the front of its grip, right around where your index finger would fall, and its main control dial behind it.

Looking at the back, it has a stills-focused control layout, with a multi-directional controller and buttons for choosing your autofocus area, setting exposure compensation and locking your exposure. The mode select dial lets you choose from the various exposure modes like manual, shutter priority, aperture priority and auto, and has a setting for video. There's also a separate record button on the top plate.

The EOS R50 V, meanwhile, has a decidedly more video-focused layout. The top plate control dial is towards the back of the camera, and the shutter button has been replaced by a record button, which is surrounded by a zoom toggle switch. The mode dial, meanwhile, flips the script from the EOS R50's: stills are relegated to a single position, while the rest of the modes are for video.

The buttons continue the video focus; while some are the same as the EOS R50's, it swaps some photo functions for quick access to white balance, color options and livestreaming modes. The multi-directional controller is swapped out for a spinning dial, though you can still press up, down, left or right to access specific functions. While we typically prefer two top-plate control dials, this rear-mounted one is better than nothing, especially when taking stills. There's also a button on the top that sets the camera to ignore input from the control dials, so you don't accidentally change your settings while vlogging.

Stills capabilities

The two cameras have very similar stills-taking capabilities. Both can shoot Raws and use electronic-first curtain shutter and a mechanical shutter to end the exposure, which eliminates concerns about rolling shutter in stills and gives you more flexibility if you're shooting with flash.

EOS R50 V | RF-S 14-30mm F4-6.3 IS STM PZ | 21mm | F5.6 | 1/1250 | ISO 100

However, the lack of an EVF on the EOS R50 V can make it difficult to judge your exposure and composition in bright sunlight. You also don't have that pop-up flash to help add some light if you need a bit of fill on your subject or are shooting in a darker environment. The default button layout for the EOS R50 is definitely more suited to shooting stills – you don't have to rely on the touchscreen as much – though spending some time to customize your button layout can alleviate that on the EOS R50 V; you can have separate settings for photo and video modes.

Video capabilities

The EOS R50 has a fair number of video capabilities. Its 4K footage is derived from 6K capture, giving it a bit of extra detail, and it has a microphone jack that'll let you record better audio. It can also shoot 10-bit HDR video, though only in the more obscure PQ response curve.

The EOS R50 V builds on top of that, with some pretty substantial additions: instead of topping out at 30fps for 4K, it can shoot at up to 60fps*, though with a substantial 1.56x crop. It also adds the ability to record C-Log 3, which gives you more flexibility to adjust color, lightness and contrast in post, and a headphone jack, so you can monitor the audio you're recording. If that wasn't enough, it includes false color assistance, which helps you nail your exposure by providing an overlay that makes it clear where your image clips and where your skin tones should be.

While both cameras have a microphone port, the EOS R50 V has subtle tweaks that make it easier to use with one. Unlike with the EOS R50, the screen won't run into the cable when you're trying to flip it out and articulate it. The actual display panel has also been moved over, so the microphone jack will mostly block your bezel rather than your preview.

* - the 4K modes above 30p aren't based on 6K capture

User Interface

The EOS R50 and R50 V have similar user interfaces, though the latter has some definite upgrades regarding video. It has an updated menu system for selecting your resolution and framerate. Rather than listing all the possible combinations of framerate, resolution, and codec, it allows you to set all three independently. This takes some getting used to, but gives you more control over what codec you want to record in, which can be especially helpful if you want to edit your footage on a less powerful device.

The EOS R50's Q menu for video mode has the same layout as it does for photo mode. The EOS R50 V's Q menu for video is a scrolling list that's a bit easier to use when you're in front of the camera.

The EOS R50 V also has an updated Q menu for video mode, giving you slightly easier access to all your settings, as well as the vlogging-specific features it has. We've found that it's a fair bit nicer for switching your most important settings during a shoot, especially if you're shooting vertically: the on-screen display gains the ability to rotate with the camera. The addition of three custom video modes also makes it particularly easy to quickly switch between resolutions, framerates and other settings without having to dive into the menus.

Ports and Connectivity

The EOS R50 has a USB-C port, microHDMI port, and a 3.5mm socket for attaching an external microphone.

The EOS R50 V has all that and more: it gains a single-pole remote terminal that lets you control the camera from afar and has a faster USB-C port. The EOS R50's USB port runs at USB 2 speeds, while the EOS R50 V's can transfer data at 10Gbps; over 20 times faster. That helps when you're offloading footage, but also has the benefit of making it a more capable webcam: while both can be used to stream video to your computer using the UVC protocol, the EOS R50 tops out at 1080p 30fps, while the EOS R50 V can deliver 4K 30fps*.

The EOS R50 V may also wirelessly transfer photos to your phone faster since it supports 5 GHz Wi-Fi as well as 2.5 GHz. The EOS R50, meanwhile, can only use 2.5 GHz.

* - The camera can't draw power from the computer when shooting at 4K, only 1080p, so you will be limited by battery life.

Price and Kit options

Body-only, the EOS R50 V costs $649, $30 less than the EOS R50. If you're looking at the kit options, though, the vlogging-focused model is more expensive; you can get it with the new RF-S 14-30mm F4-6.3 IS STM PZ lens for $849. The EOS R50, meanwhile, comes with the collapsable RF-S 18-45mm F4.5-6.3 IS STM for $799.

While the 18-45mm's wider range makes it a better pick if you're shooting a wide variety of subjects, if you mainly intend to vlog, you'll appreciate the wider field-of-view on the 14-30mm. That's especially true if you plan on features that add crops, such as 60 fps or electronic stabilization; the lens is still wide enough to produce a reasonable frame while vlogging. The powerzoom is also nice to have, especially since it's quiet enough that the camera's internal microphones don't pick it up, and you never have to worry about having to extend it when you're trying to capture a moment quickly.

Conclusion

If you're looking for a camera to mostly shoot stills or mostly shoot video, it's pretty easy to pick between the EOS R50 and EOS R50 V. It's a little trickier if you want to do both; while the latter has a compelling list of video features that aren't available on the former, they do come at the cost of a viewfinder, which can also be useful for videographers (providing they're filming something other than themselves).

EOS R50:

Buy now:

$629 at Amazon.comBuy at B&H PhotoBuy at MPB

However, if you think you'll end up shooting a lot of video, the EOS R50 V has more features and capabilities that will likely come in handy.

EOS R50 V:

Buy now:

Buy w/ 14-30mm at Amazon.comBuy w/ 14-30mm at B&H PhotoBuy w/ 14-30mm at Canon

Immune system found to trigger fear, but psychedelics block it

Gizmag news -

A new study has uncovered a previously unknown link between the immune system and the fear response, and how psychedelics can play a role in suppressing it. The finding could improve the treatment of both mental, emotional and physical afflictions.

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Category: Psychedelics, Medical Innovations, Body & Mind

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Autonomous road-to-rail truck to begin hauling cargo this year

Gizmag news -

Dual-mode vehicles that can travel on roads and rails have been around for a while now, with the idea first having been explored over a century ago. In 2025, we're going autonomous: a Utah-based startup is set to launch a pilot project running its autonomous road-rail vehicle on California's Skunk Train route this year.

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Category: Transport

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Single hair-like electrode outperforms traditional 21-lead EEG

Gizmag news -

Researchers have developed a 3D-printable electrode that looks like a single strand of human hair and measures brain activity more reliably than the current method used to diagnose things like epilepsy and sleep disorders.

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Category: Medical Devices, Medical Innovations, Body & Mind

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Watch: Volkswagen camper van pop-slide roof explodes interior space

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We already knew that Tonke had a different spin on the pop-up camper roof in store for the new Volkswagen ID. Buzz, but we didn't previously know exactly how it worked. The Dutch camper specialist released a video this month showing the new expandable sleeper roof design in action and detailing a few specs and advantages. The new pop-top leverages aspects of rooftop tent design to create a larger bed and more spacious living area, bringing a new level of comfort to all-electric ID. Buzz camping.

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Category: Automotive, Transport

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Tamron is shifting where its lenses are made because of US Tariffs

Digital Photography Review news -

Tamron recently built a second factory in Vietnam.

Photo: Tamron

Quarterly financial results for brands are trickling out, and a common theme so far is the impact of the US tariffs on production and pricing. Last week, Canon publicly discussed that it would be raising prices, likely only in the US, because of the tariffs. Now, Tamron has released its Q1 financial results, with the release detailing changes to production in response to the tariffs.

While Tamron's materials for its Q1 financial results don't share as much as Canon's, they do provide some insight into what the brand is doing in response to the US tariffs that went into effect at the beginning of April. In the materials, Tamron calls out that it is looking to "strengthen the global tripolar (Japan, China, Vietnam) production system." As part of that, the company began production at its new factory in Vietnam in February, citing "geopolitical risks, along with rising tariffs on Chinese imports" as reasons for building the second factory in the country.

Production at its second Vietnam factory began in February this year.

Photo: Tamron

According to Tamron's financials, it currently produces approximately 25% of its products in Vietnam, 65% in China and 10% in Japan. However, it is aiming to adjust that by 2028, reducing the amount produced in China to 45% while increasing the amount produced in Vietnam to 45%. Additionally, Tamron says it will reduce its parts procurement from China to 20% this year, down 10% from the current amount.

Tamron didn't specify any plans for shifting production specifically for its Photographic Products category. However, roughly 15% of that segment is produced in China, with approximately 60% coming from Vietnam and 25% from Japan. That could be good news for US consumers, since most of its lenses come from countries with lower tariffs for US imports than China. However, it isn't clear how many parts for those lenses come from China.

Tamron thinks that further cost reductions could help absorb the impact of tariffs

Even with the uncertainty surrounding the tariffs, Tamron hasn't changed its initial forecast for the year in light of its progress in Q1, saying that it exceeded its plan. That's despite a slump in sales in the US market as well as a "reactionary decline in China market," since it says gross profit increased as a result of "cost reductions and productivity improvements." Tamron thinks that further cost reductions could help absorb the impact of tariffs, but added that the tariff situation is fluid and it will "consider possible measures to minimize the impact." It didn't specify if some of those measures could mean increased prices in the US.

Tamron added, "From the 2nd quarter, uncertainty and economic slowdown are expected to increase further due to the expanding impact of US tariffs, rekindling of trade friction, and the continuing weakening of the USD and strengthening of the JPY." The US tariff situation continues to be a constantly evolving situation, so only time will tell what the actual impact will be.

The company has already announced one lens this year – the 18-300mm F3.5-6.3 Di III-A VC VXD lens to RF mount and Z mount – and says five more are coming.

Image: Tamron

The financial results presentation also contained some more exciting news: Tamron plans to release six new models in 2025, up from the company's typical five lenses per year. That includes the already announced Tamron 18-300mm f/3.5-6.3 Di III-A VC VXD, which is Tamron's seventh model for Nikon Z-mount and the second model for Canon RF mount. Even better, it says that it will have 10 new models (including variants for different mounts) per year starting in 2026.

The Ozempic pill is on the way, but one big US company won't be making it

Gizmag news -

This time next year, you may be swapping your GLP-1 injections for easier and as-effective oral weight-loss medication. It's also likely to be cheaper and not suffer the same kind of supply-chain shortages that existing therapeutics have faced. But it's been a dramatic few weeks for the leading three drug-makers vying to usher in this new phase of weight-loss treatment.

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Category: Obesity, Illnesses and conditions, Body & Mind

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