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Powerful new oral painkiller blocks signals without sedation or addiction

Gizmag news -

Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. In clinical trials so far, it has provided powerful pain relief without sedation or risk of addiction.

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Category: Chronic Pain, Illnesses and conditions, Body & Mind

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The DPReview team picks a camera for our new Community Manager

Digital Photography Review news -

Earlier this week, we introduced our new Community Manager, Mathew Anderson. He's joining our team to help manage the online forums and, like most of us here, is enthusiastic about photography. After joining, he mentioned he was potentially interested in upgrading his camera, something the rest of the team had an opinion or two on.

Rather than hiding the discussion away in Slack, we thought it would be a fun exercise to have him on the show to discuss his wants and needs for a new camera, and to go over some of the cameras that met his criteria. You can watch the discussion above, and if you have any recommendations we missed, be sure to head over to our forums to share them with Mathew and the rest of the team!

A new type of vaccine is needle-free and doubles as dental floss

Gizmag news -

In a recent experiment that sounds more sci-fi than science class, researchers have successfully developed a novel vaccine platform that uses ordinary dental floss embedded with tiny dissolvable microneedles. The study, published in Nature Biomedical Engineering, showcases how everyday materials can be reimagined to offer adaptable and accessible vaccine solutions.

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Category: Infectious Diseases, Illnesses and conditions, Body & Mind

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Affordable tech-packed scooter rides 60s retro vibe

Gizmag news -

CFMoto has established a reputation for creating some of the best value-for-money motorcycles in the world. Want an able, go-anywhere adventure moto? You have the Ibex 450. Want a sexy sportsbike? You have the 675SS. Or perhaps a naked streetfighter? There’s the 800NK – all brilliantly priced while offering impressive specs.

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Category: Motorcycles, Transport

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Scientists just uncovered four distinct genetic subtypes of autism

Gizmag news -

Imagine autism not as a single puzzle, but as a gallery of mosaics, each piece shaped by different traits, genes, and life experiences. Scientists have long known the condition is complex, but cracking the code has been a challenge.

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Category: Learning & Memory, Brain Health, Body & Mind

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Airstream's tiniest aluminum pod campers gain serious X factor

Gizmag news -

The Basecamp has long served as Airstream's most affordable, adventurous little riveted aluminum camper pod. With the addition of a lifted off-road package in 2018, it also became the company's most rugged camping trailer ... optionally. For the 2026 model year, Airstream extends that off-road package to the entire lineup, ensuring every new Basecamp rolls off the line with the chops to rattle, rumble and kick up dust on the way to distant alpine lakesides, hilltop vistas and red rock notch.

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Category: Camping Trailers, Adventure Vehicles, Outdoors

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Meike's latest autofocus lens is a 24mm F1.4 for L, Z and E mount

Digital Photography Review news -

When you use DPReview links to buy products, the site may earn a commission. Image:Meike

Meike's 24mm F1.4 'Mix,' a wide-angle full-frame autofocus lens for Nikon Z, Sony E and L mount that it showed off earlier this year, is now available. While there isn't a ton of information available about the lens, the company says it's made for "creators who see in full frame."

According to the company's spec sheet, the lens is made of 15 elements in 12 groups, though it doesn't mention what kind of special glasses (if any) are used in its optical formula. According to the company's Instagram, its aperture has 11 blades and a minimum focus distance of 0.28m (11").

Image: Meike

It has a stepper motor for autofocus, and a switch on the lens barrel for quickly switching between auto and manual focus modes. Just above that is a customizable button, and rounding out its physical design is an aperture ring, though it's unclear whether it has clicked delinations or not.

The lens can accept 72mm filters, and the E-mount version weighs 556g (19.6oz).

It costs $589, and the E and Z-mount versions are available now on Meike's site. The company says you'll be able to order the L mount version on August 20th.

Sony E mount

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Nikon Z mount

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L mount

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TTArtisan's new full-frame 'normal' lens is fast and cheap

Digital Photography Review news -

When you use DPReview links to buy products, the site may earn a commission. Image: TTArtisan

TTArtisan has announced the AF 40mm F2, a 'normal' focal-length prime for full-frame Sony E and Nikon Z mount cameras. (An L-mount version is "coming soon" according to an Instagram post from the company.) It's made to be fast, compact and affordable despite having features like a clicking aperture ring and all-metal construction.

The lens is made of nine elements in six groups, with two high-index elements, one extra-low-dispersion element and one aspherical lens. It has seven aperture blades, and can focus on objects as close as 0.4m (15.7").

Autofocus is handled by a stepping motor. The lens can fit 52mm filters, and weighs 167g (5.9oz), despite being made out of aluminium. It also comes with a metal, petal-shaped lens hood.

The lens is available now from TTArtisan's website and only costs $168, which is a very approachable price. If you've never shot with a 'normal' focal length lens before (as in, a lens that offers a field of view that's close to what the human eye does), it could be an affordable way to try it out.

Buy at TTArtisan TTArtisan AF 40mm F2 Specifications: Principal specifications Lens Type Prime Max Format size 35mm FF Focal length 40mm Image Stabilization No Lens mount Nikon Z, Sony E, Sony FE Aperture Maximum aperture F2 Minimum aperture F16 Aperture ring Yes Number of diaphragm blades 7 Optics Elements 9 Groups 6 Focus Minimum focus 0.4m (15.7") Autofocus Yes Motor type Stepper Motor Physical Weight 167g Diameter 61mm Length 44mm Sealing No Filter thread 52mm Hood supplied Yes Material Aluminium

Film Friday: A modern take on the Polaroid SX-70 folding camera is coming

Digital Photography Review news -

Image: 10Art.CC

For those interested in instant photography (and even many who are not), the Polaroid SX-70 is an icon. And now, Chinese manufacturer 10Art.CC is aiming to introduce a modern take on the foldable instant camera. The Pocket Fold 66 promises compact instant photography reminiscent of the classic Polaroid camera.

For those who are unfamiliar, the Polaroid SX-70 is a folding, single-lens reflex instant camera made by Polaroid from 1972 to 1981. It folds down to a flat rectangle and pops up when it's time to take photos. The original model was manual focus only, though a later model featured sonar autofocus.

The Polaroid SX-70 folds down into a compact rectangle when not in use.

Photo: Abby Ferguson

In its announcement post, 10Art.CC says it was inspired by the SX-70 because of its portability and image quality. The company previously released an instant film back for Hasselblad cameras as well as a standalone camera module, the former addressing quality, the latter offering portability. However, neither device satisfied the company's quest for both in one package.

The Pocket Fold 66 aims to address both of the company's goals in a single camera, just as the SX-70 did. However, it makes it clear that this isn't a replica of the classic SX-70. "Please note, this isn't a replica; it's a re-creation," it said in the announcement. "We've only retained its folding structure, as it's the only way to achieve extreme compactness. I deeply admire Dr. Land's ingenuity. Respect!"

Details are limited, but 10Art.CC says that it "optimized all components and redesigned the entire optical system, electronic system, and mechanical transmission system."

Image: 10Art.CC

The company says the Pocket Fold 66 will be a foldable instant camera with an optical viewfinder, automatic metering and EV adjustment. It will feature a 110mm F5.6 lens, though the 35mm equivalent isn't provided. The lens will reportedly offer macro capability and the ability to focus from 15cm (5.9") to infinity. The camera is indeed quite compact, apparently folding down to 16 x 10 x 4.5cm (6.3 x 3.9 x 1.8"). For comparison, the original SX-70 measured 18.4 x 10.2 x 2.5cm (7.25 x 4 x 1").

10Art.CC also says that the camera will feature a built-in rechargeable lithium battery. It claims the camera will use "Polaroid square photo paper." That is a little surprising, since most non-Polaroid instant cameras – like the folding model TTartisan announced earlier this year – use Instax film, which is more affordable and easier to find.

There is currently no price or estimated availability date, but the single image in the announcement says 2025. We may be able to expect more details later this year, then.

The hidden nerve superhighway that turns a chill on your skin into a feeling

Gizmag news -

We've long known how the nerve endings in our skin detect cold and swiftly relay the information to our brains, but we haven't understood exactly how it works. Scientists have now solved the puzzle, unlocking the mystery of this temperature pathway.

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Category: Biology, Science

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Chilling 66-million-year-old discovery rewrites primate origin story

Gizmag news -

A groundbreaking study has traced the 66-million-year evolutionary history of primates and overturned conventional thought that our ancestors originally inhabited warm tropical forests. Using advanced statistical and climate-modeling techniques, researchers have discovered that the earliest members of our evolutionary family tree were in fact cold-climate survivors.

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Category: Biology, Science

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